![]() ![]() ![]() ![]() In addition, 32.8% of MUCH patients had high out-of-clinic 24-hour-urinary aldosterone (≥ 12μg), but normal clinic SA (<15ng/dL) & ARR (<20). The two groups did not differ in SA, PRA or aldosterone-renin ratio (ARR) collected in clinic. MUCH patients had significantly higher out-of-clinic levels of 24-hour-urinary aldosterone, catecholamines and metanephrines compared to true CHTN. Sixty-four patients had MUCH and the remaining 48 patients had true CHTN. ![]() Out-of-clinic ABP monitoring and 24-hour-urinary aldosterone, catecholamines and metanephrines were also measured. All patients were evaluated by clinic automated office BP and morning serum aldosterone (SA) and plasma renin activity (PRA). Patients taking mineralocorticoid receptor antagonists and epithelial sodium channel blockers were excluded. Two-hundred-twenty-two patients were recruited after having controlled office BP readings at ≥3 clinic visits. The aim is to test the hypothesis that MUCH patients have higher aldosterone secretion compared to patients with true controlled hypertension (CHTN). Previously, we have shown that patients with MUCH have evidence of heightened out-of-clinic sympathetic nervous system (SNS) activity. Masked uncontrolled hypertension (MUCH) in treated patients is defined as controlled office blood pressure (BP) but uncontrolled out-of-clinic ambulatory BP (ABP). ![]()
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